There are two ways to open the safe:
- Mickey can destroy the wooden beam supporting the safe with thinner. This will cause the safe to fall and crush Pirate Moody. The safe cannot kill him, as he is a toon. This will not only complete the quest but will fail the other quest "Paint Moody's House". This will free Gremlin Prescott.
- For the paint path, Mickey must paint Moody's unpainted house first and then talk to him. Next, he must jump on the top of the gag factory to the safe. The screen will fade to a cutscene where Mickey opens the safe to free Gremlin Prescott.
- In Epic Mickey 2: The Power of Two, the thinner path is considered canon.
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